In water-quality management problems, uncertainties may exist in a number of impact factors and pollution-related processes (e.g., the volume and strength of industrial wastewater and their variations can be presented as random events through identifying a statistical distribution for each source); moreover, nonlinear relationships may exist among many system components (e.g., cost parameters may be functions of wastewater-discharge levels). In this study, an inexact two-stage stochastic quadratic programming (ITQP) method is developed for water-quality management under uncertainty. It is a hybrid of inexact quadratic programming (IQP) and two-stage stochastic programming (TSP) methods. The developed ITQP can handle not only uncertainties expressed as probability distributions and interval values but also nonlinearities in the objective function. It can be used for analyzing various scenarios that are associated with different levels of economic penalties or opportunity losses caused by improper policies. The ITQP is applied to a case of water-quality management to deal with uncertainties presented in terms of probabilities and intervals and to reflect dynamic interactions between pollutant loading and water quality. Interactive and derivative algorithms are employed for solving the ITQP model. The solutions are presented as combinations of deterministic, interval and distributional information, and can thus facilitate communications for different forms of uncertainties. They are helpful for managers in not only making decisions regarding wastewater discharge but also gaining insight into the tradeoff between the system benefit and the environmental requirement.