[HTML][HTML] Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

…, S Anzick, K Barbian, T Cihlar, C Martens, DP Scott… - Nature, 2020 - nature.com
Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While
many investigational, approved, and repurposed drugs have been suggested as potential …

Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection

…, HA Young, DS Reed, JB Geisbert, DP Scott… - The American journal of …, 2003 - Elsevier
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many
ways appears to be similar in humans and nonhuman primates; however, little is known about …

[HTML][HTML] Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

…, AL Rasmussen, F Feldmann, A Okumura, DP Scott… - Nature medicine, 2013 - nature.com
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global
concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 …

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

…, MT Ferris, R Green, F Feldmann, SM Kelly, DP Scott… - Science, 2014 - science.org
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …

Antibodies are necessary for rVSV/ZEBOV-GP–mediated protection against lethal Ebola virus challenge in nonhuman primates

…, WL Shupert, D Brining, DP Scott… - Proceedings of the …, 2013 - National Acad Sciences
Ebola viruses cause hemorrhagic disease in humans and nonhuman primates with high
fatality rates. These viruses pose a significant health concern worldwide due to the lack of …

[HTML][HTML] Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

…, L Bollinger, D Safronetz, F de Kok-Mercado, DP Scott… - Viruses, 2012 - mdpi.com
Historically, mice and guinea pigs have been the rodent models of choice for therapeutic
and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, …

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

…, M Morrow, KA Kraynyak, AS Khan, DP Scott… - Science translational …, 2015 - science.org
First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging
human coronavirus, which is distinct from the severe acute respiratory syndrome …

VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain

…, E Haddock, F Feldmann, PW Hanley, DP Scott… - Science, 2015 - science.org
The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and
Liberia, creating a global public health crisis and accelerating the assessment of …

[HTML][HTML] Infection with MERS-CoV causes lethal pneumonia in the common marmoset

…, R LaCasse, T Liu, J Zhu, JS McLellan, DP Scott… - PLoS …, 2014 - journals.plos.org
The availability of a robust disease model is essential for the development of countermeasures
for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque …

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions

…, S Herold, C Becker, DP Scott… - European …, 2016 - Eur Respiratory Soc
A major cause of respiratory failure during influenza A virus (IAV) infection is damage to the
epithelial–endothelial barrier of the pulmonary alveolus. Damage to this barrier results in …