[HTML][HTML] Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
…, S Anzick, K Barbian, T Cihlar, C Martens, DP Scott… - Nature, 2020 - nature.com
Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While
many investigational, approved, and repurposed drugs have been suggested as potential …
many investigational, approved, and repurposed drugs have been suggested as potential …
Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
…, HA Young, DS Reed, JB Geisbert, DP Scott… - The American journal of …, 2003 - Elsevier
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many
ways appears to be similar in humans and nonhuman primates; however, little is known about …
ways appears to be similar in humans and nonhuman primates; however, little is known about …
[HTML][HTML] Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
…, AL Rasmussen, F Feldmann, A Okumura, DP Scott… - Nature medicine, 2013 - nature.com
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global
concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 …
concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 …
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …
Antibodies are necessary for rVSV/ZEBOV-GP–mediated protection against lethal Ebola virus challenge in nonhuman primates
…, WL Shupert, D Brining, DP Scott… - Proceedings of the …, 2013 - National Acad Sciences
Ebola viruses cause hemorrhagic disease in humans and nonhuman primates with high
fatality rates. These viruses pose a significant health concern worldwide due to the lack of …
fatality rates. These viruses pose a significant health concern worldwide due to the lack of …
[HTML][HTML] Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers
…, L Bollinger, D Safronetz, F de Kok-Mercado, DP Scott… - Viruses, 2012 - mdpi.com
Historically, mice and guinea pigs have been the rodent models of choice for therapeutic
and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, …
and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, …
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates
…, M Morrow, KA Kraynyak, AS Khan, DP Scott… - Science translational …, 2015 - science.org
First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging
human coronavirus, which is distinct from the severe acute respiratory syndrome …
human coronavirus, which is distinct from the severe acute respiratory syndrome …
VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain
…, E Haddock, F Feldmann, PW Hanley, DP Scott… - Science, 2015 - science.org
The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and
Liberia, creating a global public health crisis and accelerating the assessment of …
Liberia, creating a global public health crisis and accelerating the assessment of …
[HTML][HTML] Infection with MERS-CoV causes lethal pneumonia in the common marmoset
…, R LaCasse, T Liu, J Zhu, JS McLellan, DP Scott… - PLoS …, 2014 - journals.plos.org
The availability of a robust disease model is essential for the development of countermeasures
for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque …
for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque …
Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions
…, S Herold, C Becker, DP Scott… - European …, 2016 - Eur Respiratory Soc
A major cause of respiratory failure during influenza A virus (IAV) infection is damage to the
epithelial–endothelial barrier of the pulmonary alveolus. Damage to this barrier results in …
epithelial–endothelial barrier of the pulmonary alveolus. Damage to this barrier results in …