[HTML][HTML] Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease
S Guettler, J LaRose, E Petsalaki, G Gish, A Scotter… - Cell, 2011 - cell.com
The poly(ADP-ribose)polymerases Tankyrase 1/2 (TNKS/TNKS2) catalyze the covalent linkage
of ADP-ribose polymer chains onto target proteins, regulating their ubiquitylation, stability…
of ADP-ribose polymer chains onto target proteins, regulating their ubiquitylation, stability…
[HTML][HTML] Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism
…, F Cong, PD Simoncic, Y Ueki, J La Rose… - Cell, 2011 - cell.com
Cherubism is an autosomal-dominant syndrome characterized by inflammatory destructive
bony lesions resulting in symmetrical deformities of the facial bones. Cherubism is caused by …
bony lesions resulting in symmetrical deformities of the facial bones. Cherubism is caused by …
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region
PM Chan, S Ilangumaran, J La Rose… - … and cellular biology, 2003 - Taylor & Francis
Genetic studies have implicated the cytosolic juxtamembrane region of the Kit receptor tyrosine
kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain …
kinase as an autoinhibitory regulatory domain. Mutations in the juxtamembrane domain …
[HTML][HTML] Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
P De Sepulveda, K Okkenhaug, J La Rose… - The EMBO …, 1999 - embopress.org
We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase
signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in …
signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in …
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
…, N Ishiyama, AA Chandrakumar, J La Rose… - Science …, 2017 - science.org
The PAR-1–MARK pathway controls cell polarity through the phosphorylation of microtubule-associated
proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …
proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …
[PDF][PDF] The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
…, OA Kent, M Medrano, D Mokady, J Normand, J Larose… - Cancer cell, 2014 - cell.com
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation
by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange …
by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange …
[PDF][PDF] Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition
Actin-based stress fiber formation is coupled to microtubule depolymerization through the
local activation of RhoA. While the RhoGEF Lfc has been implicated in this cytoskeleton …
local activation of RhoA. While the RhoGEF Lfc has been implicated in this cytoskeleton …
A point mutation in CD28 distinguishes proliferative signals from survival signals
K Okkenhaug, L Wu, KM Garza, J La Rose… - Nature …, 2001 - nature.com
Upon interaction with its ligand, B7, CD28 becomes phosphorylated on tyrosines. One tyrosine
in particular (Y 170 in mouse CD28, Y 173 in human CD28) has received much attention. …
in particular (Y 170 in mouse CD28, Y 173 in human CD28) has received much attention. …
[HTML][HTML] Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1
D Meiri, CB Marshall, D Mokady, J LaRose… - Nature …, 2014 - nature.com
The RhoGEF GEF-H1 can be sequestered in an inactive state on polymerized microtubules
by the dynein motor light-chain Tctex-1. Phosphorylation of GEF-H1 Ser885 by PKA or PAK …
by the dynein motor light-chain Tctex-1. Phosphorylation of GEF-H1 Ser885 by PKA or PAK …
GEF-H1 is necessary for neutrophil shear stress–induced migration during inflammation
Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress
caused by blood flow. The mechanism that couples shear stress to migration has not been fully …
caused by blood flow. The mechanism that couples shear stress to migration has not been fully …